COLLECTION / RePLLAy
Advanced Regenerative Medical Implant
RePLLAy
Versatile Collagen Restoration · Lifting · Contouring
APHORAGE GLORYAL® REPLLAY is an advanced dual regeneration biostimulatory filler combining cross-linked hyaluronic acid and PLLA microspheres to deliver immediate volumization and prolonged collagen stimulation. Its slow-release technology promotes progressive skin regeneration, enhanced firmness, and long-lasting facial rejuvenation for up to 24 months.
HA Concentration
Cross-linked HA 20 mg/ml
PLLA Content
18% microspheres
Microsphere Size
20–50 µm
Duration
Up to 24 months
Clinical Application
Treatment Areas
Temporal area — restores volume and enhances structure
Brow bone — lifts and defines the brow arch
Chin and jawline — improves definition and contour
Deep malar muscle — adds volume and support for midface rejuvenation
About
RePLLAy — Full Description
A next-generation regenerative biostimulatory filler engineered to provide progressive facial rejuvenation through an advanced dual-regeneration slow-release mechanism. Combining cross-linked hyaluronic acid with poly-L-lactic acid (PLLA) microspheres at 180mg/ml, the formulation delivers both immediate volumetric correction and sustained collagen stimulation — promoting long-term structural restoration and natural facial revitalization. Specifically developed for advanced lifting, contouring, and structural enhancement, RePLLAy is highly effective for restoring facial support and definition in the temporal region, brow bone, nose, columella, chin, jawline, nasal base, and deep malar region. Advanced microsphere suspension technology ensures uniform PLLA distribution throughout the HA matrix, optimising tissue integration and minimising local aggregation for predictable aesthetic outcomes.
Technical Data
Specifications
Cross-linked HA + PLLA 18% | 20–50 µm microspheres | Up to 24 months | 2 × 1ml
HA Concentration
Cross-linked HA 20 mg/ml
PLLA Content
18% microspheres
Microsphere Size
20–50 µm
Duration
Up to 24 months
Volume
2 × 1ml
Release Mechanism
Dual-phase slow-release
Packaging
2 syringes × 1ml pre-filled
Dual-Phase Action
How RePLLAy Works
01
Phase 1
Months 6-9
PLLA microspheres initiate collagen stimulation while hyaluronic acid gradually metabolises, providing hydration and dermal restructuring. Results: immediate hydration, improved skin quality, early collagen formation, and enhanced tissue support.
02
Phase 2
Months 9-18
PLLA microspheres progressively biodegrade and release lactic acid, reactivating and intensifying collagen synthesis. Results: peak collagen production, enhanced skin firmness, structural reinforcement, and long-term volume restoration.
03
Long-Lasting Effects
Up to 24 Months
Advanced slow-release regeneration mechanism continuously supports dermal remodelling over time. Results: sustained improvement in skin texture, elasticity, facial volume, and natural rejuvenation.
Proprietary Technology
PLLA Dual-Regeneration Slow-Release Mechanism
RePLLAy’s proprietary microsphere architecture controls the release kinetics of poly-L-lactic acid with precision. Microspheres sized 20–50 µm are optimised for phagocytic uptake by fibroblasts — maximising the neocollagenesis stimulus while maintaining biocompatibility throughout the degradation cycle. The advanced microsphere suspension technology ensures uniform PLLA distribution throughout the hyaluronic acid matrix, optimising tissue integration and minimising local aggregation.